Thinking of agile manufacturing through highly innovative projects such as, for example, robofacturing or the rationalization of production starting from the centrality of the robot and no longer of the human operator. Ideas that well represent the goal of the second open call promoted by Digital Innovation Hub² (DIH²), a European network created as part of the Horizon 2020 program for robotics in flexible production, whose Italian reference is Create-DIH, the Research Consortium for Energy, Automation and Electromagnetic Technologies (Create), which includes several southern universities.